ACETYL-GLUTATHIONE

Acetyl-Glutathione is a powerful antioxidant, anti-inflammatory, and wellness agent.  
Glutathione is known as the master antioxidant and is highly active in human lungs and many other organ systems and tissues.  It has a critical role in protecting cells from oxidative stress and maintaining the immune system.  Acetyl-Glutathione has selective apoptosis action.  Higher blood levels of glutathione have been associated with better health.
 
 

Research

 
 
Neurodegenerative diseases      
 
Mischley LK, Conley KE, Shankland EG, et al.  Central nervous system uptake of intranasal glutathione in Parkinson's diseaseNPJ Parkinsons Dis, 2016; 2:16002.         
 
Saharan S, Mandal PK.  The emerging role of glutathione in Alzheimer's diseaseJ Alzheimers Dis, 2014; 40(3):519-29.        
 
Cacciatore I, Baldassarre L, Fornasari E, Mollica A, Pinnen F.  Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systemsOxid Med Cell Longev, 2012; 2012:240146.      
 

Alternative Oral Formulations        
 
Buonocore D, Grosini M, Giardina S, et al. Bioavailability Study of an Innovative Orobuccal Formulation of GlutathioneOxid Med Cell Longev, 2016; 2016:3286365.          
 
 
Anti-aging properties         
 
Homma T, Fujii J.  Application of Glutathione as Anti-Oxidative and Anti-Aging DrugsCurr Drug Metab, 2015; 16(7):560-71.     
 
 
Dermatological       
 
Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P.  Glutathione and its antiaging and antimelanogenic effectsClin Cosmet Investig Dermatol, 2017; 10:147-153.  

Watanabe F, Hashizume E, Chan GP, Kamimura A.  Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol, 2014; 7:267-74.     

 
Immune Function      
 
Sinha R, Sinha I, Calcagnotto A, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune functionEur J Clin Nutr, 2018; 72(1):105-111.         
 
Richie JP Jr, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathioneEur J Nutr, 2015; 54(2):251-63.     
 
   
Kovacs-Nolan J, Rupa P, Matsui T, et al. In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementationJ Agric Food Chem, 2014; 62(39):9499-506. 
 
Exercise   
 
Aoi W, Ogaya Y, Takami M, et al.   Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolismJ Int Soc Sports Nutr, 2015; 12:7. 
 
 
    Autism

Kern J, Geier D, Adams J, Garver C, Audhya T, Geier M.  A clinical trial of glutathione supplementation in autism spectrum disordersMed Sci Monit, 2011; 17(12): CR677–CR682.   


Osteoporosis
 
Lean J, Davies J, Fuller K, et al. A crucial role for thiol antioxidants in estrogen-deficiency bone lossJournal of Clinical Investigation, 2003; 112(6):915-923.
 
 
Antiviral Therapy        
 
 
Fraternale A, Brundu S, Magnani M.  Glutathione and glutathione derivatives in immunotherapyBiol Chem,  2017; 398(2):261-275.          
 
 
Fraternale A, Schiavano GF, Paoletti MF, et al. Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages.  Med Microbiol Immunol, 2014; 203(4):283-9.         
 
Borges-Santos MD, Moreto F, Pereira PC, Ming-Yu Y, Burini RC.  Plasma glutathione of HIV⁺ patients responded positively and differently to dietary supplementation with cysteine or glutamine. Nutrition, 2012; 28(7-8):753-6.          
 
Fraternale A, Paoletti MF, Casabianca A, et al.  GSH and analogs in antiviral therapy.  Mol Aspects Med, 2009; 30(1-2):99-110.         
 
Fraternale A, Paoletti M, Casabianca A, et al. Inhibition of murine AIDS by pro-glutathione (GSH) moleculesAntiviral Research, 2008;  77(2):120-127.
 
Palamara AT, Brandi G, Rossi L, et al.  New synthetic glutathione derivatives with increased antiviral activitiesAntivir Chem Chemother, 2004; 15(2):83-91. 
 
Vogel J, Cinatl J, Dauletbaev N, et al. Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infectionMed Microbiol Immunol, 2003; 194(1-2):55-59.
 
 
Cancer
 
 
Balendiran GK, Dabur R, Fraser D.  The role of glutathione in cancerCell Biochem Funct, 2004; 22(6):343-52.    

Locigno R, Pincemail J, Henno A, Treusch G, Castronovo V.  S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanismInt J Oncol, 2002; 20(1):6975.
 

 
 
 
 
 
 
 
 
 
 
 
 
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