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Oxytocin

Oxytocin is a nonapeptide (nine amino acids) hormone secreted by the posterior pituitary. Oxytocin produces action both peripherally and in the brain. Oxytocin is released by males and females during orgasm and is considered by many to be the hormone of desire, social recognition and bonding. 

 

Traditionally, Oxytocin has been administered by injection or nasal spray  because oral dose forms would be destroyed by the gastrointestinal tract. Belmar Pharmacy compounds new options for patients in both an Oral Tablet of Oxytocin in our BLA System and a Sublingual tablet which is dissolved under the tongue.

The oral tablet version from Belmar utilizes our proprietary 
BLA System which is designed to present Oxytocin to the lymphatic network for absorption. Click on BLA System for more information about our absorption mechanism. 

Tablets (both oral and sublingual) are more convenient than injections and nasal sprays. They are scored for dosing options, stable and travel well. 

Oxytocin has recently received significant interest in the Autism community. Researchers have found that autistic children have lower plasma levels of oxytocin than those of other children. Oxytocin plays a role in social behavior, including but not limited to: repetitive behaviors, the desire to form social bonds, social recognition, processing social cues, regulated feeding, excessive grooming, stress response and being aloof.

For more information on the use of Oxytocin in Autism Spectrum Disorder click the link below:

http://www.youtube.com/watch?v=BEAgT91XV5A&feature=related

Oxytocin has also become the subject of studies in female sexual dysfunction specifically difficulty achieving orgasm. Oxytocin increases sexual receptivity and counteracts impotence. (Pedersen, C.A., 2002), (Arletti, 1997)
For more information on its use for this condition click the link below to see a presentation by Dr. Jorge Flechas:

http://www.youtube.com/watch?v=Y2mHO6QrKV0&feature=related

 

Oxytocin has action on uterine contraction, milk letdown, orgasm, sexual arousal, bonding and maternal behavior. Side effects of Oxytocin from the literature on injection and nasal include: hemorrhage in the brain and uterus, increased blood pressure, heart rate and cardiac output, uterine contractions.

 

 

References:

Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, Mosovich S (2003): Oxytocin infusion reduces repetitive behaviors in adults with autistic and Aspberger’s disorders.  Neuropsychopharmacology 28:193-198.

Insel TR, O’Brien DJ, Leckman JF (1999): Oxytocin, vasopressin, and autism: is there a connection?  Biol Psychiatry 45:145-147.

McCarthy MM, Altemus M (1997): Central nervous system actions of oxytocin and modulation of behavior in humans. Mol Med Today 3:269-275.

Modahl C, Green L, Fein D, Waterhouse L, Feinstein C, Morris M, Levin H (1998): Plasma oxytocin levels in autistic children.  Biol Psychiatry 43:270-277.

Panksepp J (1992): Oxytocin effects on emotional processes: separation distress, social bonding, and relationships to psychiatric disorders.  Ann NY Acad Sci 652:243-252.

Popik P, Vetulani J, van Ree JM (1992): Low doses of oxytocin facilitate social recognition in rats. Psychopharmacology (Berl)  106:71-74

Waterhouse L, Fein D, Modahl C (1996): Neurofunctional mechanisms in autism. Psychol Rev 103:457-489.

Carmichael MS, Humbert R, Dixen J, et al. Plasma Oxytocin increases in the human sexual response. J Clin Endcrinol Metab, 1987. 64:27-31.

Oxytocin Cellular and Molecular Approaches in Medicine and Research. Ivell, R and Russell, J, editors.

Oxytocin-Induced Penile Erection, Role of Nitric Oxide. Argiolas, A and Melis, M. Cagliari, Italy: 247; 1995. Plenum Press, New York.

Oxytocin Cellular and Molecular Approaches in Medicine and Research. Increased female sexual response after Oxytocin. Anderson-Hunt M and Dennerstein L. Brit Med J 309:929: 236; 1994 Plenum Press, New York.

http://www.reuniting.info/science/oxytocin_health_bonding; accessed December 2007.
Oxytocin increases sexual receptivity and counteracts impotence. (Pedersen, C.A., 2002), (Arletti, 1997)

Package Insert for Pitocin and Syntocinon from www.drugs.com accessed December 2007.

 

 

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